The horse is a domesticated single-toed hoofed mammal. It belongs to the taxonomic equine family, one of the two extant subspecies of equid. With the development of the times, the main uses of horses have gradually shifted from warfare and transportation to recreation, sports and fitness, and biological product development. The development of modern horse industry plays an important role in promoting economic development. Equine infectious diseases and lentiviral diseases, such as horse piriformis, equine protozoal myelitis, and equine herpes virus, are widely prevalent around the world, causing huge economic losses to the horse industry. Therefore, the development of antibodies for equine immune response studies is important for the diagnosis of equine diseases. Equine AntibodiesBecause horses have many naturally occurring diseases with similar conditions in humans, their availability for environmental control experiments and induced disease studies makes them a valuable intermediate model between mouse studies and human clinical trials. The study of equine antibodies is critical to the control of equine diseases and the development of drugs for related diseases. Although equine antibodies have been extensively studied by researchers since the 1970s, a more comprehensive understanding of equine antibodies has only been achieved in recent years. Currently, researchers have developed a series of monoclonal and polyclonal antibodies against equine cell surface markers (e.g., CD2, CD4, CD8, CD13, etc.), equine immunoglobulins (IgM, IgD, IgA, IgE and IgG), and equine cytokines (e.g., chemokines, interferons, interleukins, etc.). Antibodies Recognizing Equine Cell Surface AntigensAntibodies Recognizing Equine CytokinesAntibodies Recognizing Equine Immunoglobulins